1542236-46-3Relevant academic research and scientific papers
One-Pot asymmetric nitro-mannich/hydroamination cascades for the synthesis of pyrrolidine derivatives: Combining organocatalysis and gold catalysis
Barber, David M.,Duris, Andrej,Thompson, Amber L.,Sanganee, Hitesh J.,Dixon, Darren J.
, p. 634 - 638 (2014/03/21)
The highly enantioselective preparation of trisubstituted pyrrolidine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This cascade approach utilizes an asymmetric bifunctional organocatalytic nitro-Mannich reaction followed by a gold-catalyzed allene hydroamination reaction. The products are afforded in good yields and excellent diastereo- and enantioselectivities.
