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CAS

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1542266-10-3

5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1542266-10-3 Structure

  • Basic information

    1. Product Name: 5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine
    2. Synonyms: 5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine
    3. CAS NO:1542266-10-3
    4. Molecular Formula:
    5. Molecular Weight: 371.893
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1542266-10-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine(1542266-10-3)
    11. EPA Substance Registry System: 5-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine(1542266-10-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1542266-10-3(Hazardous Substances Data)

1542266-10-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1542266-10-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,4,2,2,6 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1542266-10:
(9*1)+(8*5)+(7*4)+(6*2)+(5*2)+(4*6)+(3*6)+(2*1)+(1*0)=143
143 % 10 = 3
So 1542266-10-3 is a valid CAS Registry Number.

1542266-10-3Downstream Products

1542266-10-3Relevant articles and documents

HEDGEHOG PATHWAY SIGNALING INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF

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Paragraph 0128; 0129, (2014/08/06)

The hedgehog (Hh) signaling pathway is a pathway which regulates patterning, growth and cell migration during embryonic development, but in adulthood is limited to tissue maintenance and repair. Mutational inactivation of the inhibitory pathway components leads to constitutive ligand-independent activation of the Hh signaling pathway, results in cancers such as basal cell carcinoma and medulloblastoma. Ligand-dependent activation of Hh signaling is involved in prostate cancer, pancreatic cancer, breast cancer and blood cancers. Therefore, inhibition of the aberrant Hh signaling represents a promising approach toward novel anticancer therapy. The invention provides novel molecules of formula I that inhibit hedgehog pathway signaling and provides therapeutic applications for the treatment of malignancies (basal cell carcinoma, medulloblastoma, glioblastoma, non-small cell lung cancer, prostate cancer, pancreatic cancer, blood cancers, mesenchymal cancers, etc.), prevention of tumor regrowth, sensitization of radio-chemo therapies, and other diseases (inflammation, fibrosis and immune disorders).

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