154230-53-2

Upstream product

• 154333-33-2 (3S)-3-hydroxy-4-(4-methoxyphenoxy)-1-trimethylsilyl-1-butyne 
• 154230-52-1 (+/-)-3-acetoxy-4-(4-methoxyphenoxy)-1-trimethylsilyl-1-butyne 
• 501012-73-3 (4S,5R)-4-Chloromethyl-5-(4-methoxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolane 
• 544455-38-1 ethyl (2E)-4-(4-methoxyphenoxy)but-2-enoate 
• 501012-68-6 [(4R,5R)-5-(4-Methoxy-phenoxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol 
• 68426-09-5 (4-methoxyphenoxy)acetaldehyde 
• 154230-50-9 (+/-)-3-hydroxy-4-(4-methoxyphenoxy)-1-trimethylsilyl-1-butyne 

Relevant academic research and scientific papers

Preparation of chiral propargylic alcohols from α,β-unsaturated esters

A series of chiral propargylic alcohols with high enantiomeric excess was prepared by asymmetric dihydroxylation of α,β-unsaturated esters, conversion of the diols to 4-(chloromethyl)-1,3-dioxolane intermediates, and base-induced elimination.

Synthesis of optically active 4-benzyloxymethyl- and 4-(4-methoxyphenoxy)methylbuten-2-olides via lipase-mediated resolution

A new preparation of optically active 4-benzyloxymethyl- and 4-(4-methoxyphenoxy)methylbuten-2-olides has been developed by employing lipase-mediated resolution and palladium-mediated carbomethoxylation as key steps.