15424-04-1Relevant articles and documents
COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Page/Page column 1900, (2017/09/15)
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
The Reaction of Bis(dimethylglyoximato)(pyridine)cobalt(I), Cobaloxime(I), with 2-(Allyloxy)ethyl Halides and the Photolysis of the Resulting Organo-cobaloximes
Okabe, Masami,Tada, Masaru
, p. 1498 - 1503 (2007/10/02)
The reactions of 2-(allyloxy)ethyl halides with cobaloxime(I) gave (tetrahydro-3-furanyl)methylcobaloximes via an electron transfer from cobaloxime(I) to the halides to give radical anions.The rupture of a halide ion to give an organic radical and the ring closure to give a (tetrahydro-3-furanyl)methyl radical are followed by the radical coupling between the organic radical and the cobaloxime(II).The structures of the organocobaloximes were determined by the analyses of the photolysis products under aerobic or anaerobic conditions.