1542609-26-6Relevant articles and documents
Synthesis of quercetin glycosides and their melanogenesis stimulatory activity in B16 melanoma cells
Yamauchi, Kosei,Mitsunaga, Tohru,Batubara, Irmanida
, p. 937 - 944 (2014/02/14)
4′-O-β-d-Glucopyranosyl-quercetin-3-O-β-d-glucopyranosyl- (1→4)-β-d-glucopyra-noside (3) was isolated from Helminthostachys zeylanica root extract as a melanogenesis acceleration compound and was synthesized using rutin as the starting material Related compounds were also synthesized to understand the structure-activity relationships in melanin biosynthesis Melanogenesis activities of the glycosides were determined by measuring intracellular melanin content in B16 melanoma cells Among the synthesized quercetin glycosides, quercetin-3-O-β-d-glucopyranoside (1), quercetin-3-O-β-d-glucopyranosyl-(1→4)-β-d-glucopyranoside (2), and 3 showed more potent intracellular melanogenesis acceleration activities than theophyline used as positive control in a dose-dependent manner with no cytotoxic effect