154261-78-6Relevant academic research and scientific papers
Synthesis of the 3-hydroxy oxiracetam enantiomers, potential nootropic drugs
Almeida,Grande,Moran,Anaya,Mussons,Caballero
, p. 2483 - 2494 (1993)
The enantioselective synthesis of the potentially nootropic compounds 3-6 is reported. Derivative 3 was obtained from the readily available L-tartaric acid, by reduction of the imide 8 prepared with methyl glycinate. The other derivatives 4-6 were obtained from the dihydroxylactam 11. Protection of one of the hydroxyl groups and a Mitsunobu reaction or triflate displacement of the other group produces the remaining stereoisomers. Aminoderivatives 25 and 27 were obtained by displacement with sodium azide and reduction.
