1542785-98-7

Upstream product

• 2033-77-4 4-(2-bromoethoxy)-1,2-dimethoxybenzene 
• 1542785-96-5 N-(2-(3,4-dimethoxyphenoxy)ethyl)-4-(trimethylsilyl)but-2-en-1-amine 
• 34622-39-4 (2S)-6-oxopipecolic acid 
• 1542785-75-0 tert-butyl 2-(3,4-dimethoxyphenoxy)ethyl(4-(trimethylsilyl)but-2-enyl)carbamate 
• 1542785-72-7 tert-butyl allyl(2-(3,4-dimethoxyphenoxy)ethyl)carbamate 
• 5150-42-5 2,3-dimethoxyphenol 

Downstream Products

• 1542786-00-4 (S)-tert-butyl 2-((2-(3,4-dimethoxyphenoxy)ethyl)(4-(trimethylsilyl)but-2-en-1-yl)carbamoyl)-6-oxopiperidine-1-carboxylate 

Relevant academic research and scientific papers

Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)

To create highly efficient inhibitors for FK506- binding proteins, a new asymmetric synthesis for pro-(S)-C5- branched [4.3.1] aza-amide bicycles was developed. The key step of the synthesis is an HF-driven N-acyliminium cyclization. Functionalization of the C5 moiety resulted in novel protein contacts with the psychiatric risk factor FKBP51, which led to a more than 280-fold enhancement in affinity. The most potent ligands facilitated the differentiation of N2a neuroblastoma cells with low nanomolar potency.

Bicyclic aza-amides for treatment of psychiatric disorders

The present invention relates to compounds of formula (I) having a bicyclic aza-amides scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said bicyclic aza-amides compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.

BICYCLIC AZA-AMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS

The present invention relates to compounds of formula (I) having a bicyclic aza-amides scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said bicyclic aza- amides compounds can be used for prophylaxis and/or treatment of psychiatric disorders and neurodegenerative diseases, disorders and conditions.