1542824-68-9Relevant academic research and scientific papers
IRON(II) CATALYSTS CONTAINING TRIDENTATE PNP LIGANDS, THEIR SYNTHESIS, AND USE THEREOF
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Paragraph 0158; 0159, (2016/11/28)
The application describes catalytic materials for hydrogenation or asymmetric hydrogenation. In particular, the application describes iron(ll) complexes containing tridentate diphosphine PNP ligands useful for catalytic hydrogenation.
Iron(II) complexes containing unsymmetrical P-N-P′ pincer ligands for the catalytic asymmetric hydrogenation of ketones and imines
Lagaditis, Paraskevi O.,Sues, Peter E.,Sonnenberg, Jessica F.,Wan, Kai Yang,Lough, Alan J.,Morris, Robert H.
, p. 1367 - 1380 (2014/02/14)
After their treatment with LiAlH4 and then alcohol, new iron dicarbonyl complexes mer-trans-[Fe(Br)(CO)2(P-CH=N-P′)][BF 4] (where P-CH=N-P′ = R2PCH2CH=NCH 2CH2PPh2 and R = Cy or iPr or P-CH=N-P′ = (S,S)- Cy2PCH2CH=NCH(Me)CH(Ph)PPh2) are catalysts for the hydrogenation of ketones in THF solvent with added KOtBu at 50 C and 5 atm H2. Complexes with R = Ph are not active. With the enantiopure complex, alcohols are produced with an enantiomeric excess of up to 85% (S) at TOF up to 2000 h-1, TON of up to 5000, for a range of ketones. An activated imine is hydrogenated to the amine in 90% ee at a TOF 20 h-1and TON 99. This is a significant advance in asymmetric pressure hydrogenation using iron. The complexes are prepared in two steps: (1) a one-pot reaction of phosphonium dimers ([cyclo-(PR2CH2CH(OH) -)2][Br]2), KOtBu, FeBr2, and Ph2PCH2CH2NH2 (or (S,S)-Ph 2PCH(Ph)CH(Me)NH2 for the enantiopure complex) in THF under a CO atmosphere to produce the complexes cis- and trans-[Fe(Br) 2(CO)(P-CH=N-P′)]; (2) the reaction of these with AgBF 4 under CO(g) to afford the dicarbonyl complexes in high yield (50-90%). NMR and DFT studies of the process of precatalyst activation show that the dicarbonyl complexes are converted first to hydride-aluminum hydride complexes where the imine of the P-CH=N-P′ ligand is reduced to an amide [P-CH2N-P′]- with aluminum hydrides still bound to the nitrogen. These hydride species react with alcohol to give monohydride amine iron compounds FeH(OR′)(CO)(P-CH2NH-P′), R′ = Me, CMe2Et as well as the iron(0) complex Fe(CO)2(P-CH 2NH-P′) under certain conditions.
