154287-31-7Relevant academic research and scientific papers
Homologs of idoxifene: Variation of estrogen receptor binding and calmodulin antagonism with chain length
Hardcastle, Ian R.,Rowlands, Martin G.,Grimshaw, Rachel M.,Houghton, John,Jarman, Michael,Sharff, Andrew,Neidle, Stephen
, p. 999 - 1004 (2007/10/03)
A series of homologs of idoxifene [1a, (E)-1-[4-(N- pyrrolidinoethoxy)phenyl]-1-(4-iodophenyl)-2-phenyl-1-butene] and selected homologs of 4-iodotamoxifen [2a, (E)-1-[4-[(N-dimethylamino)ethoxy]phenyl]- 1-(4-iodophenyl)-2-phenyl-1-butene] with the side ch
Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer
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, (2008/06/13)
Compounds of the general formula (2) STR1 wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R 1 and R 2, which may be the same or different, represent C 1-3 alkyl, especially methyl or ethyl, groups or R l represents a hydrogen atom and R 2 a C 1-3 alkyl group or R 1 and R 2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers.
