1542908-88-2Relevant academic research and scientific papers
3-Arylcoumarins: Synthesis and potent anti-inflammatory activity
Pu, Wenchen,Lin, Yuan,Zhang, Jianshuo,Wang, Fei,Wang, Chun,Zhang, Guolin
supporting information, p. 5432 - 5434 (2015/01/08)
Chronic inflammation is the persistent and excessive immune response and can lead to a variety of diseases. Aiming to discover new compounds with anti-inflammatory activity, we report herein the synthesis and biological evaluation of 3-arylcoumarins. Thirty five 3-arylcoumarins were prepared through Perkin condensation and further acid-promoted hydrolysis if necessary. In lipopolysaccharide-activated mouse macrophage RAW264.7 cells, 6,8-dichloro-3-(2-methoxyphenyl)coumarin (16) and 6-bromo-8-methoxy-3-(3-methoxyphenyl)coumarin (25) exhibited nitric oxide production inhibitory activity with the IC50 values of 8.5 μM and 6.9 μM, respectively, providing a pharmacological potential as anti-inflammatory agents.
