154306-83-9

Downstream Products

• 154306-84-0 methyl (2R,3S)-2-hydroxy-3-[(S)-1-phenyl]ethylamino-3-(4-fluorophenyl)propionate 
• 157240-38-5 methyl (2R,3S)-3-amino-2-hydroxy-3-(4-fluoro-phenyl)propionate 
• 154306-85-1 methyl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-(4-fluorophenyl)propionate 
• 154306-86-2 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 143527-64-4 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 
• 143527-61-1 3'-dephenyl-3'-(4-fluorophenyl)docetaxel 
• 143527-60-0 C₄₉H₅₄Cl₆FNO₁₈ 
• 143527-63-3 C₅₂H₅₈Cl₆FNO₁₈ 

Relevant academic research and scientific papers

Process for the preparation of β-phenylisoserine and β-lactam and their analogues

The present invention relates to new process for the preparation of β-phenylisoserine and its analogues of general formula: STR1 which are particularly useful for preparing taxane derivatives which have remarkable antitumour and antileukaemic activities.

Process for the preparation of β-phenylisoserine and its analogues

This invention relates to a method for preparing β-phenylisoserine and analogues thereof having general formula (I) STR1 from an aromatic aldehyde and an α-methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of g

A Practical Access to Chiral Phenylisoserinates, Preparation of Taxotere Analogs

A practical diastereoselective synthesis of phenylisoserine methyl esters 8a-c is described using α-methyl-benzylamine as the chiral template of a Staudinger reaction.Optically pure diastereoisomers 6a-c were easily recovered by crystallization.After opening of these intermediate azetidinones by hydrochloric acid and methanol, regioselective cleavage of the chiral auxiliary was achieved by hydrogenation over palladium.Phenylisoserinates 8b,c were used to prepare analogs of Taxotere.