15433-88-2Relevant academic research and scientific papers
Intramolecular Cyclopropanation Reaction of Furanyl Diazo Ketones
Padwa, Albert,Wisnieff, Thomas J.,Walsh, Edward J.
, p. 299 - 308 (1989)
α-Diazo ketones derived from furanyl- and benzofuranylpropionic acids were prepared, and their rhodium(II) acetate catalyzed behavior was studied.The results are consistent with a mechanism in which the key step involves addition of a keto carbenoid intermediate on to the furanyl ?-bond followed by an electrocyclic ring-opening reaction.In the case of the benzo-substituted furanyl system, the suspected bicyclic intermediate was isolated in high yield and its chemistry was subsequently investigated.The bicyclic ketone derived from 1-diazo-4-(2-benzofuryl)-2-butanone undergoes a novel thermal rearrangement to a benzopyranone derivative.This unexpected transformation can be rationalized in terms of a -cycloreversion reaction to give an ortho-quinoidal intermediate, which undergoes a subsequent electrocyclic ring closure followed by a 1,3-hydrogen shift.Furans with side chains of various lengths containing a diazomethyl keto group were also studied.The cyclization chemistry of the closely related diazothienylalkanone system was investigated and found to give products derived from an analogous intramolecular cyclopropanation reaction.
The synthesis and some chemical reactions of a5a-methyl 2H-naphtho[1,8-bc]furan
Burns,Taylor,Rodrigo
, p. 42 - 50 (1994)
A synthesis of the tricycle 19 has been completed in 14% overall yield from guaiacol. Several chemical transformations of this compound including its reduction to an octahydro naphtho[1,8-bc]furan and conversion to the hitherto unknown azuleno[8,1-bc]furan ring system are described.
BENZOFURAN AMIDES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY
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Page/Page column 90; 106, (2019/01/07)
The present invention relatesto a pharmaceutical composition comprising acompound of the formula Ias described belowor a tautomeror a pharmaceutically acceptable salt thereof; to the compound of the formula Ias described below or a tautomer or a phar- mac
3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES
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Page/Page column 85, (2010/02/10)
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.
