154333-14-9

Upstream product

• 137071-45-5 24,33-bis-OTBDMS-ascomycin 
• 74-88-4 methyl iodide 
• 740834-72-4 6-(tert-butyl-dimethyl-silanyloxy)-4-{2-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-vinyl}-9-ethyl-16,20-dihydroxy-15,17-dimethoxy-5,11,13,19-tetramethyl-3-oxa-22-aza-tricyclo[18.6.1.0^1,22]heptacos-10-ene-2,8,21,27-tetraone 
• 186581-53-3 diazomethane 
• 740834-86-0 C₅₅H₉₉NO₁₃Si₂ 

Relevant academic research and scientific papers

On the reactivity of ascomycin at the binding domain. Part 2: Hydroxide mediated rearrangement reactions

The natural product ascomycin represents a highly functionalised 23-membered macrocycle with a polyketide backbone. Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. Herein, highly stereoselective, hydroxide mediated rearrangement reactions at the binding domain are reported.