154343-48-3Relevant academic research and scientific papers
SYNTHESIS OF 2,5,8(1H)-QUINOLINETRIONE DERIVATIVES THROUGH VILSMEIER-HAACK FORMYLATION OF 2,5-DIMETHOXYANILIDES
Alonso, Miguel Angel,Blanco, M del Mar,Avendano, Carmen,Menendez, J. Carlos
, p. 2315 - 2326 (2007/10/02)
The preparation of 2,5,8(1H)-quinolinetrione derivatives bearing both electron-withdrawing and electron-releasing groups at C3 is described.The reaction sequence employed involves Vilsmeier-Haack cyclization of 2,5-dimethoxyanilides into 3-substituted 5,8-dimethoxy-2-chloroquinolinolines, followed by hydrolysis to the corresponding 2(1H)-quinolinones and oxidative demethylation with cerium ammonium nitrate.
