154361-48-5

Basic information

• Product Name: Arcitumomab
• Synonyms: Arcitumomab;Arcitumomab [usan:inn];Cea-scan
• CAS NO: 154361-48-5
• Mol File: 154361-48-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Arcitumomab(CAS DataBase Reference)
• NIST Chemistry Reference: Arcitumomab(154361-48-5)
• EPA Substance Registry System: Arcitumomab(154361-48-5)

Safety Data

• Hazardous Substances Data: 154361-48-5(Hazardous Substances Data)

Usage

Uses

Monoclonal antibody CEA-Scan (Immunomedics) [Note—The clinically administered preparation is the monoclonal antibody (arcitumomab) labeled with technetium Tc 99m, or technetium Tc 99m arcitumomab The CAS name for this preparation is Immunoglobulin G 1 (mo.

General Description

Arcitumomab (CEA-Scan) is a murine monoclonal Fab’fragment of IMMU-4, an MAb generated in murine ascitesfluid. Both IMMU-4 and arcitumomab react with carcinoembryonicantigen (CEA), a tumor-associated antigenwhose expression is increased in various carcinomas, especiallythose of the GI tract. The preparation is a protein,murine Ig Fab fragment from IgG1, for chemical labelingwith Tc-99m.Arcitumomab/Tc-99m is for use with standard diagnosticevaluations for detecting the presence, location, andextent of recurrent or metastatic colorectal carcinoma involvingthe liver, extrahepatic abdomen, and pelvis, with ahistologically confirmed diagnosis. IMMU-4 (and the Fab’fragments of arcitumomab) bind to carcinoembryonic antigen(CEA), whose expression is increased in carcinoma.Arcitumomab/Tc-99m is injected, and the radionuclidescan is read 2 to 5 hours later.