(Gly21)-Amyloid β-Protein (1-40) is a peptide consisting of 1-40 amino acid residues derived from the amyloid β-protein, which is a significant component of amyloid plaques in the brains of Alzheimer's disease patients. The presence of glycine at position 21 in the peptide sequence is indicated by the inclusion of Gly21 in its name. This specific form of amyloid β-protein has been extensively studied for its role in the pathogenesis of Alzheimer's disease and its potential as a therapeutic target for developing treatments for the disease.
154362-03-5
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Basic information
- Product Name: (Gly21)-Amyloid β-Protein (1-40)
- Synonyms: (Gly21)-Amyloid β-Protein (1-40);(Gly21)-AMyloid β-Protein (1-40) AMyloid β-Protein (1-40) FleMish Mutation, AMyloid β-Protein (1-40) A21G;(Gly21)-AMyloid b-Protein (1-40);AMyloid b-Protein (1-40) FleMish Mutation, AMyloid b-Protein (1-40) A21G;H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH;(Gly21)-Amyloid beta-Protein (1-40)
- CAS NO:154362-03-5
- Molecular Formula: C19H12FN5O3S2
- Molecular Weight: 441.4586832
- EINECS: N/A
- Product Categories: N/A
- Mol File: 154362-03-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (Gly21)-Amyloid β-Protein (1-40)(CAS DataBase Reference)
- NIST Chemistry Reference: (Gly21)-Amyloid β-Protein (1-40)(154362-03-5)
- EPA Substance Registry System: (Gly21)-Amyloid β-Protein (1-40)(154362-03-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 154362-03-5(Hazardous Substances Data)
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154362-03-5 Usage
Uses
Used in Pharmaceutical Industry:(Gly21)-Amyloid β-Protein (1-40) is used as a therapeutic target for the development of drugs to treat Alzheimer's disease. Its aberrant aggregation and accumulation in the brain are closely associated with the development of the disease, making it a critical focus of research in the field of neurodegenerative diseases.
Used in Research and Development:
(Gly21)-Amyloid β-Protein (1-40) is used as a research tool to study the molecular mechanisms underlying Alzheimer's disease. Understanding the interactions and pathways involving this peptide can help in the development of novel therapeutic strategies and potential drug candidates to combat the disease.
Used in Diagnostic Applications:
(Gly21)-Amyloid β-Protein (1-40) can be used as a biomarker for the detection and diagnosis of Alzheimer's disease. The presence and levels of this peptide in the brain or cerebrospinal fluid can provide valuable information about the disease progression and the effectiveness of potential treatments.
Used in Drug Delivery Systems:
(Gly21)-Amyloid β-Protein (1-40) may be used in the development of targeted drug delivery systems, where the peptide could be employed as a carrier or a targeting moiety to enhance the delivery of therapeutic agents specifically to the affected brain regions in Alzheimer's disease patients.
Check Digit Verification of cas no
The CAS Registry Mumber 154362-03-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,3,6 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 154362-03:
(8*1)+(7*5)+(6*4)+(5*3)+(4*6)+(3*2)+(2*0)+(1*3)=115
115 % 10 = 5
So 154362-03-5 is a valid CAS Registry Number.
154362-03-5Upstream product
154362-03-5Downstream Products
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(Gly21)-Amyloid β-Protein (1-40)
