154365-90-9Relevant academic research and scientific papers
One-pot green synthesis of thiazolo[3,2-a]pyridine derivatives via tandem cyclization in aqueous media
Boominathan, Muthusamy,Nagaraj, Muthupandi,Maheshwaran, Chellaiah,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai
, p. 244 - 248 (2014)
Facile, three-component domino reactions of readily available thioglycolic acid/ethyl thioglycolate, aromatic aldehydes, and malononitrile/ethyl cyanoacetate in aqueous potassium carbonate at room temperature afforded thiazolo[3,2-a]pyridine derivatives chemoselectively in good to excellent yield. All the formed 4H-chromenes were characterized by spectral and X-ray methods.
Method and catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives
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Paragraph 0067; 0068; 0069, (2017/07/20)
The invention discloses a method and a catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives, and belongs to the technical field of organic chemical industry. Magnetic material loaded alkaline ionic liquid is used as the catalyst, a molar ratio of aromatic aldehyde to active methylene compounds to methyl thioglycolate in preparation reaction is 2:(2-2.5):1, the molar weight, which is computed on the basis of alkaline ionic liquid on load, of the magnetic material loaded alkaline ionic liquid, which is the catalyst, is 8-12% of the molar weight of the methyl thioglycolate, and the reflux reaction time is 17-67 min. Compared with other preparation methods, the method and the catalyst have the advantages that the catalyst is low in loss during recycling and is high in recyclable times and product selectivity, integral preparation procedures are simple, convenient and economical, and accordingly industrial large-scale production can be facilitated.
SYNTHESIS THROUGH REACTIONS OF NUCLEOPHILES WITH ACRYLONITRILES, PART 13: A DIRECT ONE-POT SYNTHESIS OF THIAZOLOPYRIDINES
Abdel-Latif, F. F.,Mohammed, Y. S.,Abdel-Ghani, H.,Ahmed, E. Kh.,El-Gawish, E. H.
, p. 251 - 256 (2007/10/02)
Several new thiazolopyridines have been synthesized by a one-pot method through the ternary condensation of aldehydes with malononitrile and thioglycolic acid.Structure and reaction pathway are also reported. Key words: Heterocycles; thiazolopyridines; an
