154374-85-3

Upstream product

• 13141-38-3 2-phenylethynylaniline 
• 76-05-1 trifluoroacetic acid 
• 536-74-3 phenylacetylene 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1353883-51-8 (E)-4-benzylidene-3-(4-methoxyphenyl)-2-(trifluoromethyl)-3,4-dihydroquinazoline 
• 1353882-85-5 2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethanamine 
• 1353882-68-4 2,2,2-trifluoro-N'-(2-(phenylethynyl)phenyl)acetimidamide 
• 1353882-88-8 (Z)-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)methanamine 
• 1353882-91-3 (Z)-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)cyclohexamine 
• 1353882-94-6 (Z)-4-methoxy-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)aniline 
• 1353882-97-9 (Z)-4-chloro-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)aniline 
• 1353883-00-7 (Z)-4-nitro-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)aniline 
• 1353882-70-8 N-cyclohexyl-2,2,2-trifluoro-N'-(2-(phenylethynyl)phenyl)acetimidamide 
• 1353882-72-0 C₂₂H₁₄ClF₃N₂ 
• 1353882-71-9 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide 
• 1353882-73-1 2,2,2-trifluoro-N-(4-nitrophenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide 
• 1353882-69-5 C₁₇H₁₃F₃N₂ 
• 1353882-67-3 N-benzyl-2,2,2-trifluoro-N'-(2-(phenylethynyl)phenyl)acetimidamide 

Relevant academic research and scientific papers

Intramolecular activation of imidate with cationic gold(I) catalyst: A new benzylation reaction of alcohols

Benzylation of alcohols with benzyl (Z)-2,2,2-trifluoro-N-(2-alkynylphenyl)acetimidates 5a-f in the presence of a cationic gold(I) catalyst was investigated. Reagent 5f was the most effective, affording benzyl ethers in good yields. Our results indicate that these gold(I)-activated imidates are effective leaving groups.

Synthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp2 C-H difluoromethylenation

A highly efficient method for the synthesis of fluorine-containing multisubstituted phenanthridines through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional-group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more-complicated polycyclic compounds were obtained through tandem Rh-catalyzed cycloaddition/C-H difluoromethylenation. This route provides convenient access to fluorine-containing polycyclic compounds. [2+2+2] Little boys: Fluorine-containing multisubstituted phenanthridines have been synthesized through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions (see scheme; FG=functional group). Polycyclic compounds were also obtained through Rh-catalyzed C-H difluoromethylenation. Copyright

A detailed study of the intramolecular hydroamination of N-(ortho-alkynyl)aryl-N′-substituted trifluoroacetamidines and bromodifluoroacetamidines

The intramolecular hydroamination of N-(ortho-alkynyl)aryl-N′- substituted trifluoroacetamidines and bromodifluoroacetamidines is studied in detail. When the substituents on the alkyne fragment are aryl and alkyl groups, 5-endo-dig cyclization occurs utilizing NaAuCl4·2H 2O as a catalyst, while 6-exo-dig cyclization proceeds in the presence of K2CO3 as a base. Interestingly, the indole derivatives are afforded with good regioselectivity via a 5-endo-dig pathway catalyzed by Cu(OAc)2 when ortho-ethynyl appears on the aryl substituent of the amidine. The electrophilic cyclization of the amidines also shows good regioselectivity under the I2/NaHCO3 system. At the end, a facile cascade synthesis of fluorinated quinazolones is described via hydroamination/ozonolysis from the corresponding amidine.