154381-01-8

Upstream product

• 154381-00-7 1,1-dimethylethyl 2-[[[2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]piperidin-1-yl]propyl]amino]pyrimidin-4-yl]carbonyl]amino]ethylcarbamate 

Downstream Products

• 154380-87-7 N-[2-[[4-(Aminocarbonyl)pyrimidin-2-yl]amino]ethyl]-2-[[3-[4-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-piperidin-1-yl]propyl]amino]pyrimidine-4-carboxamide 

Relevant academic research and scientific papers

2-AMINO-N-[[4-(AMINOCARBONYL)-PYRIMIDIN-2-YL]AMINO]-ALKYL]PYRIMIDINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

A compound which is a pyrimidine-4-carboxamide derivative of the general formula (I) STR1 in which n is 0 or 1, m is 0 or 1, R 1 represents a methyl group whenR. sub.2 represents a phenoxy(C 1-C 4)alkyl group (in which the phenoxy group optionally carries 1 or 2 substituents selected from halogen atoms and methoxy groups), orR 1 and R 2 form together with the nitrogen atom to which they are attached a 4-phenoxypiperidin-1-yl group (in which the phenoxy group optionally carries 1 or 2 substituents selected from halogen atoms and methoxy groups), a phenoxymethylpiperidin-1-yl group (in which the phenoxy group optionally carries 1 or 2 C 1-C 4 alkyl groups) or a 4-phenylpiperazin-1-yl group (in which the phenyl group optionally carries 1 or 2 substituents selected from halogen atoms and methoxy groups), and R 3 represents a hydrogen atom or only when n is 1 a hydroxyl group or a methoxy group, or is an addition salt thereof with an acid, is useful as an α-adrenergic antagonist.