1544-85-0

Basic information

• Product Name: 2,2-Difluoro-5-aminobenzodioxole
• Synonyms: IFLAB-BB F2108-0168;2,2-DIFLUORO-5-AMINOBENZODIOXOLE;2,2-DIFLUORO-5-AMINO-1,3-BENZODIOXOLE;2,2-DIFLUORO-BENZO[1,3]DIOXOL-5-YLAMINE;5-AMINO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-AMINO-2,2-DIFLUOROBENZODIOXOLE;3,4-[(Difluoromethylene)dioxy]aniline;5-Amino-2,2-difluoro-1,3-benzodioxole, 97+%
• CAS NO: 1544-85-0
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• EINECS: -0
• Product Categories: Heterocycles series
• Mol File: 1544-85-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 95-97°C 12mm
• Flash Point: 95-97°C/12mm
• Appearance: /
• Density: 1.51 g/cm³
• Vapor Pressure: 0.0208mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Room temperature.
• PKA: 4.18±0.40(Predicted)
• Water Solubility: Not miscible or difficult to mix in water.
• Sensitive: Light Sensitive
• BRN: 1343593
• CAS DataBase Reference: 2,2-Difluoro-5-aminobenzodioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Difluoro-5-aminobenzodioxole(1544-85-0)
• EPA Substance Registry System: 2,2-Difluoro-5-aminobenzodioxole(1544-85-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 20/21/22-36/37/38-52-43-36
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1544-85-0(Hazardous Substances Data)

Usage

Uses

5-Amino-2,2-difluoro-1,3-benzodioxole is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H5F2NO3/c8-7(9)13-6-3-1-5(2-4-6)10(11)12/h1-4,7H

Upstream product

• 1583-59-1 2,2-difluoro-1,3-benzodioxole 
• 1645-96-1 2,2-difluoro-5-nitrobenzo[d][1,3]dioxolane 

Downstream Products

• 659726-70-2 3-[(2,2-difluoro-1,3-benzodioxol-5-yl)imino]-1-(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 682340-40-5 4'-(2-benzyloxyethyl)-6-methylbiphenyl-2-carboxylic acid (2,2-difluorobenzo[1,3]dioxol-5-yl)amide 
• 872707-15-8 N-(2,2-difluoro-1,3-benzodioxol-5-yl)-2-nitrobenzamide 
• 1037763-48-6 4,6-dibromo-2,2-difluorobenzo[d][1,3]dioxol-5-amine 
• 1144500-98-0 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-thiourea 
• 1334047-66-3 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-methylphenyl)methylphosphonate 
• 1334047-63-0 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-chlorophenyl)methylphosphonate 
• 1334047-68-5 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-nitrophenyl)methylphosphonate 
• 1334047-64-1 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-ethoxyphenyl)methylphosphonate 
• 1334047-65-2 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-hydroxyphenyl)methylphosphonate 
• 1334047-67-4 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-methoxyphenyl)methylphosphonate 
• 1334047-70-9 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(2-hydroxyphenyl)methylphosphonate 
• 1334047-72-1 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(3-chlorophenyl)methylphosphonate 
• 1334047-62-9 diethyl (2,2-difluorobenzo[d][1,3]dioxol-5-ylamino)(4-bromophenyl)methylphosphonate 

Relevant articles and documents

Bactericide and application thereof

The invention relates to the technical field of agriculture, in particular to a bactericide. The bactericide comprises a compound in a formula (A) as shown in the specification, wherein X1 and X2 areselected from fluorine and chlorine and can be identical or different, R1 and R2 are selected from aliphatic alkyls in carbon number of 1-20 and aryls formed by carbon and hydrogen and in carbon number of 6-20, and R is selected from aliphatic alkyls in carbon number of 1-20.

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.