15441-67-5

Upstream product

• 3031-66-1 3-hexyn-2,5-diol 
• 65983-88-2 5-tetrahydropyran-2-yloxy-hex-3-yn-2-one 
• 271598-41-5 5-trimethylsilanyloxy-hex-3-yn-2-ol 

Downstream Products

• 63359-63-7 2,5-dimethyl-3-methylsulfanyl-furan 
• 55764-22-2 S-(2,5-dimethylfur-3-yl) thioacetate 
• 1028277-45-3 Benzoic acid 1-methyl-4-oxo-pent-2-ynyl ester 
• 57556-12-4 3-methoxy-2,5-dimethyl-furan 
• 54415-31-5 hex-3-yne-2,5-dione 
• 28588-73-0 bis (2,5-dimethyl-furan-3-yl)-disulfide 
• 61197-06-6 methyl 2,5-dimethylfur-3-yl disulfide 
• 55764-23-3 3-mercapto-2,5-dimethylfuran 
• 161637-38-3 C₁₃H₁₂⁽²⁾H₂O₃ 
• 161637-33-8 (E)-5-benzoyloxyhex-3-en-2-one 
• 161637-34-9 (Z)-5-benzoyloxyhex-3-en-2-one 
• 14400-67-0 2,5-dimethyl-2,3-dihydrofuran-3-one 

Relevant academic research and scientific papers

A convenient preparation of 3-Acetyl-5-methylisoxazole

Starting from 2,5-hexanedione (4), a one-pot preparation of 3-acetyl-5-methylisoxazole (1) is described. 3-Acetyl-5-methylisoxazole (1) is a useful compound for the preparation of 3-oxobutyronitrile (10) and for 3-vinyl-(5-methyl isoxazolyl) ketone (2).

New approach to 1-substituted-1,2-alkadiene-phosphonates III. Synthesis of 2-keto-5-methyl-3,4-hexadienyl-3-phosphonate dimethyl esters

The synthesis of the titled compounds have been discussed.

A new approach to 1-substituted-1,2-alkadiene-phosphonates III: Synthesis of 2-keto-5-methyl-3,4-hexadienyl-3-phosphonate dimethyl esters

Abstract: The synthesis of the titled compounds have been discussed. Copyright Taylor & Francis Inc.

Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors

The present invention relates to compounds of formula whereinX is —S— or —NH—; R3/R4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7 membered ring, which optionally contains in addition to the N-atom one additional heteroatom selected from the group consisting of O, S and N, and wherein the ring is optionally substituted by hydroxy, lower alkyl, lower alkoxy, —NR2, —CONR2, —CO-lower alkyl or benzyl; or R3/R4 form together with the N-atom to which they are attached a heterocyclic ring system, containing two or three rings and which optionally contains one or two additional heteroatoms selected from the group consisting of N and O and which has no more than 20 carbon atoms; and R, R1, R2, and R5 are as defined herein and to pharmaceutically suitable acid addition salts thereof. It has been found that the compounds of the invention are active on the GABAB receptor and therefore are useful for the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders and gastro-intestinal disorders.

4- (SULFANYL-PYRIMIDIN-4-YLMETHYL) -MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY

The present invention relates to compounds of Formula (I) wherein X is-S-or-NH-; R1 is alkyl, alkenyl, arylalkyl, arylalkenyl or aryl-O-alkyl, wherein the aryl groups are optionally substituted by one or more substituents, selected from the group consisting of lower alkyl, lower alkoxy, halogen or lower halogen-alkyl; R2 is hydrogen, lower alkyl or cycloalkyl; R3 /R4 may form together with the N-atom to which they are attached a non aromatic5, 6 or 7 membered ring, which may contain in addition to the N-atom one additional heteroatom selected from the group consisting of O, S or N, and wherein the ring is optionally substituted by hydroxy, lower alkyl, lower alkoxy,-NR2,-CONR2,-CO-lower alkyl or benzyl; or may form together with the N-atom to which they are attached a heterocyclic ring system, containing at least two rings and which may contain one or two additional heretoatoms, selected from the group consisting of N or O; R is hydrogen or lower alkyl; R5 is hydrogen or lower alkyl; and to pharmaceutically suitable acid addition salts thereof. It has been found that the compounds are active on the GABAB receptor and therefore useful for the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders or gastro-intestinal disorders.

Selective oxidation of acetylenic 1,4-diols with dioxiranes in comparison with the methyltrioxorhenium-hydrogen peroxide oxidant

Dimethyldioxirane (DMD) and its trifluoro analog (TFD) were employed to achieve selectively the direct transformation of diol 3a and of diol 3b into the corresponding carbonyls. The results are compared with oxidations using methyltrioxorhenium (MTO)/85%

Organic Heterocyclothiazenes. Part 5. Cycloaddition Reactions of Tetrasulphur Tetranitride with Highly Electron Deficient Alkynes

In contrast with previous, complex, S4N4-alkyne reactions, treatment of butynedinitrile and S4N4 is found to give 1,3,5,2,4-trithiadiazepine-6,7-dicarbonitrile (8) and 1,2,5-thiadiazole-3,4-dicarbonitrile (9) very cleanly and in high yield.Hexafluorobut-2

A NEW REACTION OF ACETYLENES, THE ADDITION OF METHANOL TO 5-HYDROXYHEX-3-YN-2-ONE. SYNTHESIS OF THE "ONION FURANONE", 2-HEXYL-5-METHYL-3-FURANONE.

The conversion of alkyl-substituted 4-hydroxybut-2-ynones to 2,5-dialkyl-3-furanones via 2,5-dialkyl-methoxyfurans is described.

Mercury in Organic Chemistry. 24. Mercuration and Subsequent Carbonylation of 4-Hydroxy-2-alkyn-1-ones: A Novel Route to Furans

Mercuric chloride readily adds to the carbon-carbon triple bond of certain 4-hydroxy-2-alkyn-1-ones (3a, 3b, and 3e) to give vinylmercurials which appear to be the first syn addition compounds of mercuric chloride.These vinylmercurials readily dehydrate to 3-furylmercurials.Palladium-promoted carbonylation of these compounds affords 3-furyl carbonyl compounds.