15442-04-3Relevant academic research and scientific papers
THE KINETIC RELATIONSHIPS OF THE REACTIONS OF N-ARYL-3-METHYLPYRAZOLE-1-CARBOXAMIDES WITH AMINES
Ivanov, M. G.,Elizarova, T. P.,Dergunov, Yu. I.
, p. 450 - 455 (2007/10/02)
The kinetics of the reaction of N-aryl-3-methylpyrazole-1-carboxamides with amines in carbon tetrachloride are described by an equation of third order in the substituted amide.At small concentrations the amine does not take part in the controlling stage of the reaction, but the transamination rate increases with increase in the concentration of the amine.It was concluded on the basis of the obtained results that the rate-controlling stages are the thermal dissociation of the substituted amide and of its complexes with amino compounds.
THE EFFECT OF SOLVENTS ON THE KINETICS OF TRANSAMINATION OF N-ARYL-3-METHYLPYRAZOLE-1-CARBOXAMIDES
Ivanov, M. G.,Elizarova, T. P.,Dergunov, Yu. I.
, p. 456 - 460 (2007/10/02)
The effect of substituents in the aromatic ring on the kinetics of the reaction of N-aryl-3-methylpyrazole-1-carboxamides with amines in various aprotic solvents is described by the Hammett equation with small positive values of ρ.A reaction mechanism, according to which the controlling stage is the removal of a proton from the nitrogen atom of the amide group, is proposed on the basis of these results and also of study of the effect of additions of hydroxyl-containing compounds.
Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
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, (2008/06/13)
Method of treating atherosclerosis with dialkylureas and dialkylthioureas, compositions thereof and processes for their preparation.
INFRARED SPECTROSCOPIC AND CONFORMATIONAL STUDIES OF TRISUBSTITUTED UREAS CONTAINING CHLOROPHENYL GROUPS
Mido, Yoshiyuki,Furusawa, Chizuko
, p. 23 - 28 (2007/10/02)
The IR spectra, in the ν(N-H) region, of trisubstituted ureas R2UPhCl and RPhUPhCl containing a chlorophenyl group have been studied in order to examine the effects of the introduced chlorine atom.The out-trans-cis isomerism about the NH-CO rotational axis is discussed in reation to steric effect of the R2 group, Ph-Ph interaction and inter- and intra-molecular hydrogen bonding.In dilute solution, R2UPhCl exists in the trans or the out form, and RPhUPhCl in the cis form. o-Chlorophenyl derivatives show a monomeric ν(N-H) band at a wavenumber lower than that of the other derivatives and no associated ν(N-H) bands in concentrated or even in saturated solutions.Some of the derivatives are found to be in the same form in the solid state as in solution due to the retention of intra-molecular NH...Cl hydrogen bonding.
