154422-95-4Relevant articles and documents
Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker
Choi, Yeon Jae,Seo, Jae Hong,Shin, Kye Jung
, p. 880 - 883 (2014/02/14)
To obtain an optimized T-type calcium channel blocker with reduced off-target hERG toxicity, we modified the structure of the original compound by introducing a zwitterion and reducing the basicity of the nitrogen. Among the structurally modified compound
Tetrahydrobenzindole compounds
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, (2010/02/05)
A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR5; each of B and Z is independently N, CH or CR1, with the proviso that A is N when B and/or Z is N; R1, R2, R3, R4and R5and n are as defined in the specification.