1544337-01-0Relevant academic research and scientific papers
Catalytic asymmetric 1,3-dipolar [3 + 6] cycloaddition of azomethine ylides with 2-Acyl cycloheptatrienes: Efficient construction of bridged heterocycles bearing piperidine moiety
Li, Qing-Hua,Wei, Liang,Wang, Chun-Jiang
supporting information, p. 8685 - 8692 (2014/07/07)
Conjugated cyclic trienes without nonbenzenoid aromatic characteristic were successfully employed as fine-tunable dipolarophiles in the Cu(I)-catalyzed asymmetric azomethine ylide-involved 1,3-dipolar [3 + 6] cycloaddition for the first time, affording a variety of bridged heterocycles bearing piperidine moiety in good yield with exclusive regioselectivity and excellent stereoselectivity. 2-Acyl group is the key factor that determines the annulation preferentially through [3 + 6]-pathway, while 2-ester group modulates the annulation through [3 + 2]-pathway.
