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154445-78-0 Usage


2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is a white to gray powdery chemical compound that is characterized by its unique molecular structure. It is a derivative of dihydrobenzofuran with five methyl groups and a sulfonyl chloride group attached to its structure. 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is known for its reactivity and is commonly used in various chemical and pharmaceutical applications due to its specific functional groups.


Used in Chemical Synthesis:
2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is used as a reagent for introducing the PBF (p-benzylphenyl) protection in arginine's guanidine group. This application is particularly important in the synthesis of complex organic molecules and pharmaceutical compounds, where the protection of specific functional groups is crucial for the successful completion of multi-step reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is used as a key intermediate in the synthesis of various drug molecules. Its unique structure and reactivity make it a valuable building block for the development of new therapeutic agents with potential applications in treating a wide range of diseases and medical conditions.
Used in Research and Development:
2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is also utilized in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its versatility and unique properties make it an attractive candidate for the development of new methodologies and the discovery of innovative applications in various fields, including materials science, agrochemistry, and environmental chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 154445-78-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,4,4 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 154445-78:
140 % 10 = 0
So 154445-78-0 is a valid CAS Registry Number.

154445-78-0 Well-known Company Product Price

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  • Sigma-Aldrich

  • (09654)  2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonylchloride  ≥95.0% (AT)

  • 154445-78-0

  • 09654-1G

  • 1,278.81CNY

  • Detail
  • Sigma-Aldrich

  • (09654)  2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonylchloride  ≥95.0% (AT)

  • 154445-78-0

  • 09654-5G

  • 4,409.73CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154445-78-0 SDS

154445-78-0Relevant articles and documents

The 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl Group (Pbf) as Arginine Side Chain Protectant

Carpino, Louis A.,Shroff, Hitesh,Triolo, Salvatore A.,Mansour, El-Sayed M. E.,Wenschuh, Holger,Albericio, Fernando

, p. 7829 - 7832 (1993)

The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl residue (Pbf) is more easily deblocked by trifluoroacetic acid (TFA) than the corresponding Pmc analog and can be used efficiently in the synthesis of arginine-containing peptides.

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