154457-10-0

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 13709-06-3 2,4-bis(methoxymethoxy)benzaldehyde 

Downstream Products

• 1083312-65-5 2,4-bis(methoxymethoxy)-1-propoxybenzene 
• 1134100-10-9 C₁₅H₂₀O₅ 
• 154457-11-1 4,6-dimethoxymethyloxy-2-dimethylaminomethylphenol 

Relevant academic research and scientific papers

Synthesis of (+/-)-Arthrographol (Asperfuran)

Arthrographol, antifungal dihydrobenzofuran, have been synthesized starting from 2,4-dihydroxybenzaldehyde in 10 steps.

NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE

Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides methods of treating ADPKD comprising administering a therapeutically effective amount of a coumarin-3-carboxamide novobiocin analogue. Accordingly, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of mTOR pathway phosphoproteins P-mTOR, P-Akt and P-S6K, or combinations thereof. Further, the method can include administering a novobiocin analogue in a therapeutically effective amount for reducing levels of Hsp-90 client proteins CFTR, ErbB2, c-Raf and Cdk4, or combinations thereof.

Synthesis and biological activity of arthrographol and related compounds

(±)- Arthrographol (1a) and related compounds were synthesized and their inhibitory activities against 5-lipoxygenase were investigated. The l'(Z)-isomer (1b) of arthrographol was found to be three times active than arthrographol itself.