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8-Hydroxymanzamine A is an alkaloid derived from manzamine A, with a hydroxy substituent at position 8. It is isolated from Pachypellina and Acanthostrongylophora, and has been found to exhibit inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

154466-37-2

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154466-37-2 Usage

Uses

Used in Pharmaceutical Applications:
8-Hydroxymanzamine A is used as a pharmaceutical compound for its inhibitory activity against Glycogen Synthase Kinase-3 (GSK-3). This enzyme plays a crucial role in various cellular processes, and its inhibition can have potential therapeutic applications in treating diseases associated with GSK-3 dysregulation.
Used in Research and Development:
8-Hydroxymanzamine A is also used as a research tool in the field of biochemistry and pharmacology. Its inhibitory activity against GSK-3 makes it a valuable compound for studying the enzyme's role in cellular processes and for developing new drugs targeting GSK-3-related pathways.
Used in Drug Discovery:
Due to its inhibitory activity against GSK-3, 8-hydroxymanzamine A can be used as a lead compound in drug discovery efforts. Researchers can use this alkaloid as a starting point to design and synthesize new drugs that target GSK-3, potentially leading to the development of novel therapeutics for various diseases.
Used in Cancer Research:
8-Hydroxymanzamine A's potential applications in cancer research should not be overlooked. Given its inhibitory activity against GSK-3, which has been implicated in cancer cell survival and proliferation, this alkaloid may have potential uses in the development of anticancer drugs or as a tool for studying the role of GSK-3 in cancer biology.

Check Digit Verification of cas no

The CAS Registry Mumber 154466-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,4,6 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 154466-37:
(8*1)+(7*5)+(6*4)+(5*4)+(4*6)+(3*6)+(2*3)+(1*7)=142
142 % 10 = 2
So 154466-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C36H44N4O2/c41-30-14-11-13-27-28-15-18-37-33(32(28)38-31(27)30)29-22-25-16-21-39-19-9-5-2-1-4-8-17-36(29,42)34-35(25,24-39)23-26-12-7-3-6-10-20-40(26)34/h1,4,7,11-15,18,22,25-26,34,38,41-42H,2-3,5-6,8-10,16-17,19-21,23-24H2/b4-1-,12-7-/t25-,26+,34-,35?,36+/m1/s1

154466-37-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-hydroxymanzamine A

1.2 Other means of identification

Product number -
Other names 1,13-Etheno-4,21a-methano-1H-azocino(1',2':1,5)pyrrolo(3,2-e)azacyclopentadecin-13(13aH)-ol,2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(8-hydroxy-9H-pyrido(3,4-b)indol-1-yl)-,(1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*))

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:154466-37-2 SDS

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