1544739-25-4

Basic information

• Product Name: 2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
• Synonyms: 2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
• CAS NO: 1544739-25-4
• Molecular Weight: 314.99
• Mol File: 1544739-25-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane(1544739-25-4)
• EPA Substance Registry System: 2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane(1544739-25-4)

Safety Data

• Hazardous Substances Data: 1544739-25-4(Hazardous Substances Data)

Usage

Molecular structure

2-(3-bromomethyl-4-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane consists of a boron atom attached to a dioxaborolane ring and a substituted phenyl group with a bromomethyl and a fluorine substituent.

Type of compound

Boron-containing compound.

Usage

It is used in various organic synthesis reactions as a reagent.

Boron atom function

Acts as a Lewis acid catalyst in organic chemistry.

Applications

Synthesis of pharmaceuticals, agrochemicals, and preparation of various polymers and organic compounds in materials science.

Value

Offers unique reactivity and selectivity in various chemical reactions.

Upstream product

• 1352733-99-3 [2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanol 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1544739-49-2 (5aR,6S,6aS)-ethyl 3-((4-fluoro-4’-((S)-2-hydroxypropoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544739-47-0 (5aR,6S,6aS)-3-((4-fluoro-4’-((S)-2-hydroxypropoxy)-2’,6’-dimethyl-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544739-59-4 (5aR,6S,6aS)-ethyl 3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544739-56-1 (5aR,6S,6aS)-3-((4-fluoro-4’-(2-(1-hydroxycyclopropyl)ethoxy)-2’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544739-68-5 ethyl 3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544739-61-8 (5aR,6S,6aS)-3-((4-fluoro-4’-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)-2’,6’-dimethyl-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544739-74-3 (5aR,6S,6aS)-ethyl 3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]-cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544739-71-0 (5aR,6S,6aS)-3-((2’,4-difluoro-4’-(3-(methylsulfonyl)propoxy)-6’-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544740-48-8 (5aR,6S,6aS)-ethyl 3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-44-4 (5aR,6S,6aS)-3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544741-33-4 (5aR,6S,6aS)-ethyl 3-((4-fluoro-2’,6’-dimethyl-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-50-2 (5aR,6S,6aS)-3-((4-fluoro-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544740-80-8 4-[2-fluoro-5-(2-trifluoromethyl-phenoxy)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid ethyl ester 
• 1544740-79-5 4-[2-fluoro-5-(2-trifluoromethyl-phenoxy)-benzyloxy]-1,1a,6,6a-tetrahydro-3-aza-cyclopropa[a]indene-1-carboxylic acid 

Relevant articles and documents

ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS

The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

ANTIDIABETIC TRICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.