15448-75-6Relevant academic research and scientific papers
Direct Cross-Couplings of Propargylic Diols
Green, Nicholas J.,Willis, Anthony C.,Sherburn, Michael S.
supporting information, p. 9244 - 9248 (2016/08/05)
[Pd(PPh3)4] catalyzes a Suzuki–Miyaura-like twofold cross-coupling sequence between underivatized propargylic diols and either aryl or alkenyl boronic acids to furnish highly substituted 1,3-dienes. Thus, 2,3-diaryl-1,3-butadienes and their dialkenic congeners ([4]dendralenes) are delivered in a (pseudo)halogen-free, single-step synthesis which supersedes existing methods. Allenols are also readily formed. Treatment of these single- and twofold cross-coupled products with acid leads to remarkably short syntheses of highly-substituted benzofulvenes and aryl indenes, respectively.
