154483-79-1

Basic information

• Product Name: N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester
• Synonyms: N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester
• CAS NO: 154483-79-1
• Molecular Weight: 415.423
• Mol File: 154483-79-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester(154483-79-1)
• EPA Substance Registry System: N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine methyl ester(154483-79-1)

Safety Data

• Hazardous Substances Data: 154483-79-1(Hazardous Substances Data)

Upstream product

• 762-04-9 Diethyl phosphonate 
• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 762-04-9 phosphonic acid diethyl ester 
• 122-52-1 triethyl phosphite 

Downstream Products

• 107658-38-8 (S)-2-Amino-3-[4-(diethoxy-phosphoryl)-phenyl]-propionic acid 
• 154483-81-5 N^α-Boc-4-(diethoxyphosphinyl)-L-phenylalanine 

Relevant articles and documents

Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites

Photoinduced phosphonation of aryl triflates with trialkyl phosphites via a tandem single-electron-transfer, C-O bond cleavage and Arbuzov rearrangement process in the absence of transition-metal and external photosensitizer is reported herein. The protoc

New- Nα-Guanidinobenzoyl Derivatives of Hirudin-54-65 Containing Stabilized Carboxyl or Phosphoryl Groups on the Side Chain of Phenylalanine-63

We report on the synthesis and pharmacological properties of a new series of thrombin inhibitors derived from hirudin carboxyl-terminal fragments.Two (arylphosphono)phenylalanines, p-PO3H2-L-Phe1 and m-PO3H2-L-Tyr, and one (carboxymethyl)phenylalanine, p-CH2COOH-L-Phe, were prepared and incorporated into position 63 of the modified hirudin's C-terminal dodecapeptide using the Fmoc solid-phase synthesis strategy.Substitution by any one of the residues led to very active analogs which doubled the thrombin time at low micromolar concentration (Ctt2) in vitro (1 μM 2 3 μM) and potently increased the activated partial thromboplastin time (APTT) ex vivo.These compounds displayed a higher potency in vitro and a longer duration of action in vivo than both the corresponding sulfated or phosphorylated tyrosine counterparts.