15452-32-1

Basic information

• Product Name: 1H-Benzimidazole, 2-[2-(4-methoxyphenyl)ethyl]-
• CAS NO: 15452-32-1
• Molecular Formula: C16H16N2O
• Molecular Weight: 252.316
• Mol File: 15452-32-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 2-[2-(4-methoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 2-[2-(4-methoxyphenyl)ethyl]-(15452-32-1)
• EPA Substance Registry System: 1H-Benzimidazole, 2-[2-(4-methoxyphenyl)ethyl]-(15452-32-1)

Safety Data

• Hazardous Substances Data: 15452-32-1(Hazardous Substances Data)

Upstream product

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB

For finding the novel inhibitor of nuclear factor κB activity, a series of benzimidazole derivatives were rationally designed, synthesized and systematically studied for their in vitro activities against LPS induced NF-κB inhibition in RAW 264.7 cells using the SEAP assay based on the flexible chalcone JSH ((E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxy phenyl)prop-2-en-1-one) which was previously reported. Although most of the benzimidazole derivatives showed strong inhibitory activity in low micromolar potency, 2-(4-methoxybenzyl)-1H-benzo[d]imidazole (3m; IC50 = 1.7 μM) and 2-(2-methoxybenzyl)-1H-benzo[d]imidazole (3n; IC50 = 2.4 μM) showed the best inhibition. The structure activity relationship revealed that 2-benzylbenzimidazole scaffold with hydrogen bonding acceptor on phenyl ring appears as a pharmacophore.