154535-08-7

Upstream product

• 519-05-1 opianic acid 
• 59276-33-4 veratraldehyde dimethyl acetal 
• 103505-13-1 (2-hydroxymethyl-3,4-dimethoxyphenyl)ethanol 

Downstream Products

• 154535-12-3 1-ethoxycarbonyl-5,6-dimethoxy-2-(3,4-dimethoxyphenyl)-3-oxo-1,2,3,4-tetrahydroisoquinoline 
• 154535-11-2 5,6-dimethoxy-2-(3,4-dimethoxyphenyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-1-carboxylic acid 
• 154535-10-1 ethyl 2-bromo-(3,4-dimethoxy-2-ethoxymethylphenyl)acetate 
• 154535-09-8 1,2-diethoxycarbonylmethyl-3,4-dimethoxybenzene 
• 85175-51-5 1,2-dicyanomethyl-3,4-dimethoxybenzene 

Relevant academic research and scientific papers

Synthesis of saulatine

A study directed toward the synthesis of saulatine (5,8,9,14a-tetrahydro- 3,4,11,12-tetramethoxy-isoquino[1,2-b]benzazepine-6,14-dione) is described. The successful synthetic route consists of three steps starting with 3,4- dimethoxyphenethylamine and 2-bromo-(3,4-dimethoxy-2- ethoxycarbomethylphenyl)-acetate. It was found that the methoxy moieties present on the aromatic rings prohibit the use of the intramolecular Friedel- Crafts reaction with a Lewis acid catalyst for ring construction because of their demethylation tendency under the reaction conditions.