154541-72-7 Usage
Originator
Alinastine ,Fabrica Espanola de
Productos Quimicos y
Farmaceuticos
Manufacturing Process
1.5 g of a sodium hydride suspension in oil are added to another suspension
of 10.83 g of 2-[1-(2-(4-(1,1-dimethylethyl)phenyl)ethyl)piperidin-4-yl]-1Hbenzimidazole
in 150 ml of dimethylformamide and the mixture is stirred for 1
h at room temperature, then a solution of 2-(2-ethoxyethyl)tosylate in
dimethylformamide are slowly added. The mixture is heated at 60°C for 16 h,
poured onto water and extracted with ether. The extracts are washed with
water, dried over anhydrous sodium sulfate and concentrated. The obtained oil
is purified by column chromatography yielding 6.0 g of 1-(2-ethoxyethyl)-2-
[1-(2-(4-(1,1-dimethylethyl)phenyl)ethyl)piperidine-4-yl]-1H-benzimidazole,
melting point 138°-140°C.
Therapeutic Function
Antihistaminic, Antiallergic
Check Digit Verification of cas no
The CAS Registry Mumber 154541-72-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,5,4 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 154541-72:
(8*1)+(7*5)+(6*4)+(5*5)+(4*4)+(3*1)+(2*7)+(1*2)=127
127 % 10 = 7
So 154541-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C28H39N3O/c1-5-32-21-20-31-26-9-7-6-8-25(26)29-27(31)23-15-18-30(19-16-23)17-14-22-10-12-24(13-11-22)28(2,3)4/h6-13,23H,5,14-21H2,1-4H3
