154593-58-5

Usage

Uses

Used in Pharmaceutical Industry:
L-2-(5-Bromothienyl)alanine is used as a precursor in the synthesis of pharmaceutical compounds for its unique structural features, which can contribute to the development of novel drugs with potential therapeutic benefits.
Used in Biotechnology Industry:
In the biotechnology sector, L-2-(5-Bromothienyl)alanine is utilized for its potential to enhance or modify the properties of biological molecules, facilitating advancements in research and the creation of innovative biotechnological products.
Used in Chemical Research:
L-2-(5-Bromothienyl)alanine is employed as a research tool in chemical laboratories to explore its unique properties and investigate its interactions with other molecules, which can lead to new discoveries and applications in the scientific community.

InChI:InChI=1/C7H8BrNO2S/c1-7(9,6(10)11)4-2-3-5(8)12-4/h2-3H,9H2,1H3,(H,10,11)/t7-/m0/s1

Upstream product

• 190319-93-8 2-acetylamino-3-(5-bromo-[2]thienyl)-propionic acid 
• 50868-68-3 (E)-3-(5-bromo-2-thienyl)-2-propenoic acid 
• 88991-26-8 2-N-acetylamino-3-(5-bromo-2-thienyl)-acrylic acid 
• 88991-50-8 5-(5-bromo-2-thienyliden)-2-methyl-3-oxazolin-4-one 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 190319-95-0 (S)-3-(5-Bromo-thiophen-2-yl)-2-tert-butoxycarbonylamino-propionic acid 

Relevant academic research and scientific papers

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination

Current routes to nitrogen-containing heteroarylalanines involve complex multistep synthesis and are often reliant on protection/deprotection steps and wasteful chromatographic purifications. In order to complement existing methodologies, a convenient telescopic strategy was developed for the synthesis of l-pyridylalanine analogues (12 examples) and other l-heteroarylalanines (5 examples) starting from the corresponding aldehydes. A phenylalanine ammonia lyase (PAL) from Anabaena variabilis was used as the biocatalyst to give conversions ranging between 88 and 95%, isolated yields of 32-60%, and perfect enantiopurity (>99% ee) by employing an additional deracemization cascade where necessary.

Thienylalanine derivatives as inhibitors of cell adhesion

The present invention relates to compounds of formula (I), in which A, B, X, Y, R1, R2, R3 and n have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They

Asymmetric synthesis of L-thienylalanines

L-Thienylalanines were prepared via the hydantoin and azlactone routes with the key step consisting of the microbial transamination of 2-hydroxy-3-thienylacrylic with L-aspartic acid as amino donor.The transamination reaction was performed by a genetically engineered E. coli strain on scales up to 100 g of L-3-(2-thienyl)alanine 1a and is also applicable to the preparation of the isomeric amino acid 1b and some ring-substituted derivatives.

Studies on Cyclic Dipeptides, I: Aryl Modifications of cyclo-[Phe-His]

Seven new cyclic dipeptides have been synthesized and tested for their applicability as tools to elucidate the mechanism of formation of mandelonitrile with (SS)-cyclo-[Phe-His] type catalysts. Conformational analyses based on 1H NMR spectra are presented for all prepared cyclic dipeptides.