154597-37-2 Usage
Molar mass
160.17 g/mol
Physical state
Yellow crystalline solid
Potential applications
Organic synthesis, pharmaceutical research
+ Indazole ring
Bicyclic heterocycle with nitrogen and carbon atoms
+ Carboxaldehyde group
A formyl group (-CHO) attached to a benzene ring
+ Amino group
Amino group (-NH2) attached to the indazole ring
Uses
+ Versatile building block for the synthesis of organic molecules and pharmaceuticals
+ Key intermediate in the production of potential drug candidates and bioactive compounds
Importance in research
+ Unique structure and reactivity for studying chemical reactions and molecular transformations in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 154597-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,5,9 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 154597-37:
(8*1)+(7*5)+(6*4)+(5*5)+(4*9)+(3*7)+(2*3)+(1*7)=162
162 % 10 = 2
So 154597-37-2 is a valid CAS Registry Number.
154597-37-2Relevant academic research and scientific papers
ANTITUMOR AGENTS. VI. SYNTHESIS AND ANTITUMOR ACTIVITY OF RING A-, RING B-, AND RING C-MODIFIED DERIVATIVES OF CAMPTOTHECIN
Sugimori, Masamichi,Ejima, Akio,Ohsuki, Satoru,Matsumoto, Kensuke,Kawato, Yasuyoshi,et al.
, p. 81 - 94 (2007/10/02)
Eleven ring A-, ring B-, and ring C-modified analogues of the antitumor alkaloid camptothecin (1) were prepared and evaluated for cytotoxicity and antitumor activity against P388 mouse leukemia.Among the six ring A-modified analogues, hexacyclic compound (14) retained the same order of activity as 1.Most of the ring B- and ring C-modified analogues displayed greatly reduced activity, whereas compound (39), which has an alkylidene group at position 5, was found to be as active as 1.These results confirmed the necessity of the intact rings A, B, and C of 1 for antitumor activity.Further, the higher activity of 14 and 39 suggest that the"northern" part of the camptothecin molecule may be a suitable site for functionalization to obtain more potent analogues of 1.
