154635-17-3

Basic information

• Product Name: efavirenz
• Synonyms: 6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one;Efavirenz [racemic]
• CAS NO: 154635-17-3
• Molecular Formula: C14H9ClF3NO2
• Molecular Weight: 315.6749696
• Mol File: 154635-17-3.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 340.6°Cat760mmHg
• Flash Point: 159.8°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 8.53E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: efavirenz(CAS DataBase Reference)
• NIST Chemistry Reference: efavirenz(154635-17-3)
• EPA Substance Registry System: efavirenz(154635-17-3)

Safety Data

• Hazardous Substances Data: 154635-17-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 209414-27-7 (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 
• 1262030-22-7 (S)-2-(5-chloro-2-((1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxamido)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-yl 1-chloroethyl carbonate 
• 1352784-88-3 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol 
• 1352784-89-4 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one 
• 6746-94-7 Cyclopropylacetylene 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 1381993-88-9 (S)-2-(2,5-dichlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol 
• 917-61-3 sodium isocyanate 
• 6361-23-5 2,5-dichloro-benzaldehyde 
• 168834-43-3 6-amino-3-chloro-α-cyclopropylethynyl-α-(trifluoromethyl)benzyl alcohol 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 

Downstream Products

• 205754-33-2 8-Hydroxyefavirenz 

Relevant articles and documents

Development and Validation of RP-Chiral HPLC Method for Determination of (R)-Enantiomer Excess Content in Efavirenz

A simple, specific, linear, accurate and precise reverse phase chiral HPLC method was developed for the separation of efavirenz enantiomers by using the Lux Amylose-2 column containing amylose tris(5-chloro-2-methyl phenyl carbamate) as a stationary phase. The mobile phase consists of 0.1 % formic acid in water and acetonitrile (55:45, v/v). The flow rate was kept at 1.0 mL/min and the detection wavelength used 252 nm and the column temperature was set at 25 oC. The limit of detection was 0.01 mg/mL and the limit of quantification was 0.04 mg/mL. The linearity calibration curve of (R)-enantiomer was shown well from the range of 0.04 mg/mL to 0.4 mg/mL. The values of the correlation coefficient were 0.999 and 0.999 for (R)-enantiomer and (S)-efavirenz, respectively. The percentage recoveries of (R)-enantiomer from efavirenz drug substance were ranged from 93.5% to 107.5%. The results demonstrated that developed RP-chiral HPLC method was simple, precise, robust and applicable for the estimation of (R)-enantiomer in efavirenz API. This method was validated in as per ICH Q2 (R1) and USP validation of compendial methods .

METHOD FOR THE MANUFACTURE OF EFAVIRENZ

This invention relates to a method for the manufacture of optically pure (S)-6- chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1 -benzoxazin- 2-one. Specifically, this invention relates to a flow synthesis method for the manufacture of (S)-6-chloro-(cyclopropylethynyl)-1,4-dihydro-4- (trifluoromethyl)-2H-3,1 -benzoxazin-2-one.

Eluent tolerance and enantioseparation recovery of chiral packing materials based on chitosan bis(phenylcarbamate)-(n-octyl urea)s for high performance liquid chromatography

The goal of the present work was to study the influence of the swelling of chitosan derivatives on the enantioseparation and the separation performance recovery of chiral stationary phases (CSPs) based on these derivatives. Therefore, six chitosan bis(phenylcarbamate)-(n-octyl urea)s were synthesized, which were coated on macroporous 3-aminopropyl silica gel affording new CSPs. Most of the CSPs demonstrated strong enantioseparation capability for the tested chiral compounds. The swelling capacity of the chitosan bis(phenylcarbamate)-(n-octyl urea)s in ethyl acetate, acetone and tetrahydrofuran (THF) was evaluated. Among the chitosan derivatives, the chitosan bis(3,5-dichlorophenylcarbamate)-(n-octyl urea) polymer showed the highest swelling capacity in ethyl acetate and THF. The polymer-based CSPs could be utilized with pure ethyl acetate and a normal phase containing 70% THF, but was damaged by pure THF. On the other hand, the separation performance of the damaged CSP could be recovered after it was allowed to stand for a period of time. The observations are important for the development and application of polysaccharide derivative-based CSPs.