1547295-75-9Relevant academic research and scientific papers
Cladosins A-E, hybrid polyketides from a deep-sea-derived fungus, Cladosporium sphaerospermum
Wu, Guangwei,Sun, Xinhua,Yu, Guihong,Wang, Wei,Zhu, Tianjiao,Gu, Qianqun,Li, Dehai
, p. 270 - 275 (2014)
Five new fungal hybrid polyketides, cladosins A-D (1-4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1-5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher's and Marfey's methods for stereochemical assignment. A plausible biogenetic pathway to 1-5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.
