154737-75-4Relevant academic research and scientific papers
Leukotriene A4 hydrolase and cyclooxygense double target inhibitors and use thereof
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, (2016/10/07)
The invention discloses a double-target inhibitor for leukotriene A4 hydrolase and cyclooxygenase as well as a purpose of the double-target inhibitor. The double-target inhibitor is a compound shown in a general formula (I), wherein X1 and X2 are respectively and independently separated into hydrogen, halogen, alkyl or alkoxy; Y represents hydrogen, hydroxyl, halogen or alkyl; Z represents substituent groups at the fourth position and/or the fifth position of a benzoyl core benzene ring, and respectively represents hydrogen, halogen, amino, alkyl acylamino, alkyl substituted amino, trifluoromethyl or carboxyl alkyl acylamino; n is 2 to 4. The compound can be used for preparing medicine for treating, preventing or inhibiting inflammation such as arthritis and rheumatoid arthritis.
De novo design of multitarget ligands with an iterative fragment-growing strategy
Shang, Erchang,Yuan, Yaxia,Chen, Xinyi,Liu, Ying,Pei, Jianfeng,Lai, Luhua
, p. 1235 - 1241 (2014/05/20)
The discovery of multitarget drugs has recently attracted much attention. Most of the reported multitarget ligands have been serendipitous discoveries. Although a few methods have been developed for rational multitarget drug discovery, there is a lack of
Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: Importance of additional hydrophobic aromatic interactions
Chen,Boiziau,Parker,Mailliet,Commercon,Tocque,Le Pecq,Roques,Garbay
, p. 845 - 859 (2007/10/02)
Potent inhibitors of EGF-dependent protein tyrosine kinase (PTK) activity were synthesized in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylates. Several of these compounds inhibited EGF-dependent DNA synthesis in ER 22 cells with IC50 1 μ
