1547458-69-4Relevant academic research and scientific papers
Intramolecular [1,4]- S - To O -Silyl migration: A useful strategy for synthesizing z -silyl enol ethers with diverse thioether linkages
Sun, Changzhen,Zhang, Yuebao,Xiao, Peihong,Li, Hongze,Sun, Xianwei,Song, Zhenlei
supporting information, p. 984 - 987 (2014/03/21)
An intramolecular [1,4]-S- to O-silyl migration has been used to form silyl enol ethers with Z-configurational control. The silyl migration also creates a new anion center at sulfur, which can subsequently react with electrophiles to generate Z-silyl enol ethers with diverse thioether linkages. The synthetic utility of this pathway was demonstrated by modifying the Z-silyl enol ethers with aldehydes via a Mukaiyama aldol reaction or Prins cyclization to generate functionalized organosulfur compounds.
