154800-89-2

Upstream product

• 154698-95-0 1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-<2-<(methoxymethyl)oxy>-4-methylphenyl>ethane 
• 154698-94-9 (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone 
• 154698-97-2 1-(tert-Butyldiphenylsiloxy)-2-cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethane 
• 154699-02-2 2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-cyclopropylideneethyl pivalate 
• 154699-01-1 2-Cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethyl pivalate 
• 154699-00-0 2-Cyclopropylidene-2-(2-hydroxy-4-methylphenyl)ethanol 
• 57234-27-2 1-(methoxymethoxy)-3-methylbenzene 
• 154699-03-3 2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-cyclopropylideneethanol 

Downstream Products

• 154699-10-2 (1R,2S)-(-)-2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-methyl-1-(triethylsiloxy)-1-vinylcyclobutanol 
• 154699-09-9 (1R,2S)-(+)-2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-methyl-1-vinylcyclobutanol 
• 154699-11-3 (3R)-(-)-3-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-3-methyl-2-methylidenecyclopentanone 
• 154699-08-8 (S)-(-)-2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-methylcyclobutanone 
• 154699-07-7 (R)-(-)-2-<2-(tert-Butyldimethylsiloxy)-4-methylphenyl>-2-<(phenylthio)methyl>cyclobutanone 

Relevant academic research and scientific papers

A Remarkable Substituent Effect on the Enantioselectivity of Tandem Asymmetric Epoxidation and Enantiospecific Ring Expansion of Cyclopropylidene Alcohols: A New Enantiocontrolled Synthesis of (-)-Debromoaplysin and (-)-Aplysin

A remarkable substituent effect by the tert-butyldimethylsiloxy group on the enantioselectivity of the tandem asymmetric epoxidation and enantiospecific ring expansion of 2--2-cyclopropylideneethanol (18), affording (S)-(-)-2--2-hydroxymethylcyclobutanone (21) in high yield and high enantiomeric excess, was observed.This enabled us to accomplish a concise and highly enantioselective total synthesis of (-)-debromoaplysin (2) and (-)-aplysin (1), providing a new and general strategy for the enantioselective synthesis of biologically important substances having the dihydrobenzofuran framework.