154810-25-0

Basic information

• Product Name: 1(2H)-Phthalazinone, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-
• CAS NO: 154810-25-0
• Molecular Formula: C14H13ClN2O
• Molecular Weight: 260.723
• Mol File: 154810-25-0.mol

Chemical Properties

• CAS DataBase Reference: 1(2H)-Phthalazinone, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Phthalazinone, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-(154810-25-0)
• EPA Substance Registry System: 1(2H)-Phthalazinone, 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-(154810-25-0)

Safety Data

• Hazardous Substances Data: 154810-25-0(Hazardous Substances Data)

Upstream product

• 52240-18-3 cis-2-(4-chlorobenzoyl)cyclohexane-1-carboxylic acid 

Downstream Products

• 561006-93-7 2-(2-cyanoethyl)-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-1(2H)phthalazinone 

Relevant articles and documents

Partial dehydrogenation of saturated 4-phenyl-1(2H)-phthalazinone derivatives by thionyl chloride

cis-4a,5,6,7,8,8a-Hexahydro-4-phenyl-1(2H)-phthalazinones (2) react with thionyl chloride in benzene to give tetrahydro derivatives (3); the corresponding reaction of methylene bridged derivatives (5) is also described.

FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT

Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.

5,6,7,8-Tetrahydro-1(2H)phthalazinone derivatives with potential pharmacological activity. Part I

N-cyanoethylation of 5,6,7,8-tetrahydro-1(2H)phthalazinones was performed with acrylonitrile in good yields in the presence of potassium carbonate and the cyanoethylated products were hydrolyzed to the corresponding acids. The structure of the new compoun

Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives

A new procedure is described for the preparation of pyridazinones from 4,5-dihydropyridazinones under mild conditions with CuCl2 in MeCN via halogenation and spontaneous HCl elimination. For the trans-hexahydrophthalazin-8(1H)-one 1B*, the HCl elimination is five times faster than for the corresponding cis isomer 1B.