154822-84-1Relevant academic research and scientific papers
A New Access to Piperidino-cyclopiperidinecarboxamides - Constrained Analogues of a Pharmaceutical used Diaminic Building Block
Vilsmaier, Elmar,Grosse, Markus,Schlag, Wolf-Ruediger,Milch, Gunther,Bergstraesser, Uwe,Ritter Von Onciul, Andreas
, p. 479 - 484 (2007/10/03)
6-Piperidino-3-azabicyclo[3.1.0]hexane-6-carboxamide diastereomers 1a and 2a represent conformationally rigid analogues of 3a which is a building block in some pharmaceutical compounds. A new access to these compounds 1a and 2a was found via the cleavage
FUNCTIONALIZED CHLOROENAMINES IN AMINOCYCLOPROPANE SYNTHESIS - XV. SYNTHESIS OF CONFORMATIONALLY RIGID ANALOGUES OF -4'-CARBOXAMIDE - A COMMON PHARMACOPHORIC GROUP
Schlag, Wolf-Ruediger,Vilsmaier, Elmar,Maas, Gerhard
, p. 3123 - 3138 (2007/10/02)
6-Piperidino-3-azabicyclohexane-6-carboxamide diastereomers 5 and 7 represent conformationally rigid analogues of the pharmacophoric group 1.Compounds 5 and 7 were synthesized with high stereoselectivity via chloroenamines 12a and 13b, respectively
