1548258-72-5Relevant academic research and scientific papers
Azo-coupling of pyrazole-3(5)-diazonium chlorides with cyanothioacetamide: A convenient synthesis of pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides
Ledenyova, Irina V.,Didenko, Vitaly V.,Dotsenko, Victor V.,Shikhaliev, Khidmet S.
, p. 1239 - 1242 (2014)
Cyanothioacetamide reacts with pyrazole-3(5)-diazonium chlorides to afford pyrazolo[5,1-c][1,2,4]triazine-3-carbothioamides 5. The latter can be oxidized with H2O2 to give either pyrazolo[5,1-c][1,2,4]triazine-3- carboxamides or 1,2,4-thiadiazole derivatives, depending on the reaction conditions. The Hantzsch-type reaction of thioamides 5 with α-bromo ketones leads to 3-(thiazol-2-yl)pyrazolo[5,1-c][1,2,4]triazines.
