1548331-45-8Relevant academic research and scientific papers
Application of substituted mono carbonyl curcumin compound containing allyl in preparing antitumor drug
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Paragraph 0093; 0116, (2017/05/02)
The invention discloses application of a substituted mono carbonyl curcumin compound containing allyl in preparing antitumor drug. The mono carbonyl curcumin compound has a structure shown in a formula (I) or a pharmaceutically acceptable salt thereof, wherein A represents C, S, or O -NR1, R1 is independently selected from one or more of H, C1-C5 alkyl, phenyl benzene and benzyl group, n is 0 or 1, R is independently selected from one or more of H, hydroxyl, C1-C4, alkoxyl, pyrrolidine, morpholinyl and methyl N-piperazine. Test results show that the mono carbonyl curcumin compound has good stability and antitumor activity, and can be used as a potential antitumor drug.
Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents
Liu, Zhiguo,Tang, Longguang,Zou, Peng,Zhang, Yali,Wang, Zhe,Fang, Qilu,Jiang, Lili,Chen, Gaozhi,Xu, Zheng,Zhang, Huajie,Liang, Guang
, p. 671 - 682 (2014/03/21)
Curcumin has been shown to possess anti-inflammatory activities but has been limited for its low stability and poor bioavailability. We have previously reported four series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MACs). In continuation of our ongoing research, we designed and synthesized 33 novel allylated or prenylated MACs here, and evaluated their anti-inflammatory effects in RAW 264.7 macrophages. A majority of them effectively inhibited the LPS-induced expression of TNF-α and IL-6, especially IL-6. The preliminary SAR and quantitative SAR analysis were conducted. Compound 14q is the most potent analog among them, and exhibits significant protection against LPS-induced death in septic mice. Together, these data present a series of new analogs of curcumin as promising anti-inflammatory agents.
