1548359-30-3Relevant academic research and scientific papers
Enantioselective Conjugate Additions of “Difficult” Ketones to Nitrodienynes and Tandem Annulations
Liu, Teng,Zhou, Mingxin,Yuan, Tengrui,Fu, Binbin,Wang, Xinran,Peng, Fangzhi,Shao, Zhihui
, p. 89 - 95 (2017)
The first enantioselective conjugate additions of problematic aromatic ketones and acetone to nitrodienynes have been achieved by employing a chiral multifunctional primary amine catalyst recently developed by us. The reactions took place in a 1,4-manner. Furthermore, by utilizing the resulting chiral functionalized 1,3-enynes as a starting point, we have developed unprecedented p-toluenesulfonic acid-catalyzed tandem annulations, which allow the efficient and selective construction of various synthetically useful cyclic 1,5-diketones (R=Ar) and dienones (R=Me). (Figure presented.).
