1548513-06-9Relevant academic research and scientific papers
Synthesis of chiral butenolides using amino-thiocarbamate-catalyzed asymmetric bromolactonization
Tan, Chong Kiat,Er, Jun Cheng,Yeung, Ying-Yeung
, p. 1243 - 1246 (2014/02/14)
The asymmetric cyclization of 4,4-disubstituted 3-butenoic acids is studied. Amino-thiocarbamates are used as the catalysts and N-bromosuccinimide is used as the stoichiometric halogen source. The resulting γ-butanolide products are readily converted into the corresponding γ-butenolides (up to 58% ee) derivatives in one-pot.
