154868-38-9Relevant academic research and scientific papers
Asymmetric aldol reactions of achiral 2-phenylsulfanyl aldehydes with small- and medium-sized carbocyclic rings: the synthesis of homochiral spirocyclic lactones, pyrrolidines and tetrahydrofurans
Chibale, Kelly,Warren, Stuart
, p. 2411 - 2419 (2007/10/02)
Chiral boron enolates based on the 1,3-oxazolidin-2-one auxiliary react with achiral 1-phenylsulfanylcycloalkanecarbaldehydes in anti- and syn-selective aldol processes to give the corresponding aldol products with moderate to excellent levels of diastereo- and enantio-control.Stereospecific cyclisation via an asymmetric episulfonium (thiiranium) ion leads to optically pure spirocyclic compounds in high chemical yields.
The stereochemically controlled synthesis of spirocyclic ethers and lactones with medium-sized (7-, 8-, and 12-membered) carbocyclic rings by phenylthio migration: 1-oxaspiro[4. n]alkanes and alkan-2-ones with N = 6, 7, and 11
Chibale, Kelly,Hartley, Richard C.,Jenkins, Kevin P.,Simons, Matthew,Warren, Stuart,Richards, Ian C.
, p. 6783 - 6786 (2007/10/02)
3-Methyl-4-phenylthio-1-oxaspiro[4.6]undecanes, [4.7]dodecanes, [4.11]hexadecanes and the corresponding 2-ones (lactones) can be made from cyclohepta-, octa-, and dodecanone by chain extension to the 2-phenylthio-carbaldehyde, stereoselective aldol reacti
