154910-85-7

Basic information

• Product Name: N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-phenylacetamide
• Synonyms: N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-phenylacetamide
• CAS NO: 154910-85-7
• Molecular Weight: 229.282
• Mol File: 154910-85-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-phenylacetamide(154910-85-7)
• EPA Substance Registry System: N-(1,3-dimethyl-1H-pyrazol-5-yl)-2-phenylacetamide(154910-85-7)

Safety Data

• Hazardous Substances Data: 154910-85-7(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 3524-32-1 5-Amino-1,3-dimethylpyrazole 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1416451-77-8 C₁₃H₁₃N₅O 
• 154910-91-5 N-(1,3-dimethylpyrazol-5-yl)phenylthioacetamide 

Relevant articles and documents

B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether

The use of B(OCH2CF3)3 for mediating direct amidation reactions of a wide range of pharmaceutically relevant carboxylic acids and amines is described, including numerous heterocycle-containing examples. An initial screen of solvents for the direct amidation reaction suggested that cyclopentyl methyl ether, a solvent with a very good safety profile suitable for use over a wide temperature range, was an excellent replacement for the previously used solvent acetonitrile. Under these conditions amides could be prepared from 18 of the 21 carboxylic acids and 18 of the 21 amines examined. Further optimisation of one of the low yielding amidation reactions (36% yield) via a design of experiments approach enabled an 84% yield of the amide to be obtained.

AN EFFICIENT PROCEDURE FOR THE SYNTHESIS OF PYRAZOLOTHIAZIN-4-ONES

Trichloromethyl chloroformate reacts with N-(1-alkyl/aryl-5-pyrazolyl)thiocarboxamides (2a-j) to give pyrazolothiazin-4-ones (3) while it reacts with N-(3-methyl-5-pyrazolyl)thiobenzamide (2m) to give the pyrazolothiadiazine-4-one (4).Heating under reflux in formic acid of homologues (3g-i) bearing a tert-butyl group linked to pyrazole N-1 atom afforded the dealkylated derivatives (3k-m).