15495-36-0

Upstream product

• 1608-42-0 benzenedizolium-2-carboxylate 
• 119219-85-1 1-Bromo-2,3,5,6-tetrahydro-8,9-dimethoxy-2,3-dioxopyrrolo<2,1-a>isoquinoline 
• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 85-52-9 2-Benzoylbenzoic acid 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 102421-38-5 2,3,5,6-Tetrahydro-8,9-dimethoxy-2,3-dioxopyrrolo<2,1-a>isoquinoline 

Relevant academic research and scientific papers

Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones

Amides and ketones were intramolecularly coupled in the presence of KOt-Bu/DMF. The reaction provided good yields of a variety of isoquinolinones. A reaction mechanism of radical addition and subsequent E2-elimination is proposed.

Cycloaddition Reactions of Isoquinoline-Pyrroline-2,3-dione and β-Carboline-Pyrroline-2,3-dione with Benzyne. Total Synthesis of 8-Oxypseudopalmatine and Decarbomethoxydihydrogambirtannine

The formation of the skeleton of protoberberines and dehydroyohimbanes by cycloaddition between pyrrolinediones and arynes is described.The total synthesis of 8-oxypseudopalmatine and decarbomethoxydihydrogambirtannine were performed.

A Regioselective Entry to 13-Substituted 8-Oxoprotoberberines. Total Synthesis of (+/-)-Corydaline

13-Alkyl and 13-aryl substituted 8-oxoprotoberberines were obtained by interamolecular benzyne cycloaddition of isoquinolinopyrrolinediones with arynes.This convergent and highly regioselective reaction has been applied to the synthesis of (+/-)-corydalin