1549574-85-7Relevant academic research and scientific papers
Metal-catalyzed [6 + 3] cycloaddition of tropone with azomethine ylides: A practical access to piperidine-fused bicyclic heterocycles
Liu, Honglei,Wu, Yang,Zhao, Yan,Li, Zhen,Zhang, Lei,Yang, Wenjun,Jiang, Hui,Jing, Chengfeng,Yu, Hao,Wang, Bo,Xiao, Yumei,Guo, Hongchao
supporting information, p. 2625 - 2629 (2014/03/21)
The first metal-catalyzed [6 + 3] cycloaddition of tropone with azomethine ylides has been developed. With the use of a chiral ferrocenylphosphine- copper(I) complex as the catalyst, the asymmetric variant of the [6 + 3] cycloaddition has also been successfully achieved. The reactions proceeded smoothly under mild conditions, affording piperidine-fused bicyclic heterocycles in moderate to high yields with good to excellent diastereo-and enantioselectivies. The procedures are operationally simple and the catalysts are cheap and readily accessible, thus providing a practical approach to piperidine-fused bicyclic heterocycles.
